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Our August cover shows the 1st recordings of gating current from voltage-gated channels, reported in 1973 by Schneider and Chandler, for the Ca channels of skeletal muscle (left), and by Armstrong and Bezanilla for the Na channels of the squid giant axon (right), and the voltage-clamp circuits used.
Catacuzzeno et al. provide a retrospective on gating currents from their first recording in 1973 to
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On our June cover: Encoding of a photocaged serine allows for site-specific control of phosphorylation with light. CFTR channels with encoded caged serine at position 813 (lower left) are marginally activated with protein kinase A activation, but upon blue light decaging (middle), the channel becomes phosphorylated and activated (right). From a study by Infield et al. (https://doi.org/10.1085/jgp.
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Our May cover shows a detailed computational model of striated muscle elucidates how mutations and drugs may alter twitch timing. The spatially explicit model simulates myosin motors connected within a compliant, contractile lattice, complete with thin filament regulation and varying mutation penetrance. The model yields data used to train classifiers.
From Asencio et al. (https://doi.org/10.1085/
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Two distinct pathways regulate chromaffin cell exocytosis.
JGP study from Morales et al. (https://rupress.org/jgp/article/155/2/e202213180/213771/PACAP-and-acetylcholine-cause-distinct-Ca2-signals) reveals how the neurotransmitter PACAP induces a secretory response in chromaffin cells that differs from the one induced by acetylcholine.
In our Research News: https://rupress.org/jgp/article/155/2
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Our August cover shows the 1st recordings of gating current from voltage-gated channels, reported in 1973 by Schneider and Chandler, for the Ca channels of skeletal muscle (left), and by Armstrong and Bezanilla for the Na channels of the squid giant axon (right), and the voltage…
Our September Issue is out! Cover image cover shows electron micrographs from fresh (top panels) and frozen-thenthawed (bottom panels) porcine myocardium in the longitudinal section showed that liquid nitrogen–freezing has only minor effec…
On our July cover:
As tropomyosin moves during its regulatory transitions from the blocking B-state (magenta) to the closed C-state (gold) during activation, it pivots about one of the helices in its coiled coil (inset boxes), exposing my…
On our June cover: Encoding of a photocaged serine allows for site-specific control of phosphorylation with light. CFTR channels with encoded caged serine at position 813 (lower left) are marginally activated with protein kinase A activati…
Our May cover shows a detailed computational model of striated muscle elucidates how mutations and drugs may alter twitch timing. The spatially explicit model simulates myosin motors connected within a compliant, contractile lattice, compl…
Our April cover illustrates an assay to estimate the likelihood of a drug being cytotoxic, based on its ability to alter bilayer elasticity & promote formation of gramicidin channels.
From Peyear and Andersen (https://doi.org/10.1085/jgp.2…
Our March cover shows mock screen of low (grey) versus high (red) Ca2+ on fluorescence lifetime in IANBD-cTnCT53C exchanged myofibrils: average lifetimes (dashes) and 3× S.D. (lines). Insets: IANBD-TnCT53C (orange-green); fluorescence micr…
Two distinct pathways regulate chromaffin cell exocytosis.
JGP study from Morales et al. (https://rupress.org/jgp/article/155/2/e202213180/213771/PACAP-and-acetylcholine-cause-distinct-Ca2-signals) reveals how the neurotransmitter PACAP …
Are you attending the Biophysical Society Annual Meeting #BPS2023 in San Diego? Please join us Sunday morning for JGP's special presentation, Advances in Membrane Physiology!
🗓️ Sunday, 2/19 11:30am-1pm
📍Room 9, San Diego Convention Center…
JGP is pleased to present a special collection of recent biophysical research articles to accompany Biophysical Society's 67th Annual Meeting #BPS2023. The collection includes a broad range of biophysical topics, including the regulation o…
On our February cover: Long-timescale molecular dynamics simulations performed under hyperpolarizing conditions show spermine unbinding from the selectivity filter of inward-rectifier Kir2.2 (cyan), leading to an inward potassium current a…
New Review: Leonit Kiriaev, Angus Lindsay et al. discuss how preparations, protocols, and factors impact sensitivity to ECC of dystrophin-deficient skeletal muscle. https://rupress.org/jgp/article/155/2/e202213208/213810/Eccentric-contract…
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